Incidence of primary cholangiocellular carcinoma of the liver in Japanese patients with hepatitis C virus–related cirrhosis

  title={Incidence of primary cholangiocellular carcinoma of the liver in Japanese patients with hepatitis C virus–related cirrhosis},
  author={M. Kobayashi and Kenji Ikeda and Satoshi Saitoh and Fumitaka Suzuki and Akihito Tsubota and Yoshiyuki Suzuki and Yasuji Arase and Naoya Murashima and Kazuaki Chayama and Hiromitsu Kumada},
Hepatitis C virus (HCV) infection is a major risk factor for the development of hepatocellular carcinoma. However, the risk factors for primary cholangiocellular carcinoma of the liver (PCC‐L) have not been fully investigated. The authors determined the incidence of PCC‐L in patients with HCV‐related cirrhosis. 

Hepatitis C virus and malignancy

  • A. SuriawinataS. Thung
  • Medicine, Biology
    Hepatology research : the official journal of the Japan Society of Hepatology
  • 2007
Hepatitis C virus is a hepatotropic virus that causes chronic hepatitis, fibrosis and cirrhosis, and its prevalence and probable oncogenesis are reviewed.

Impact of hepatitis C virus on survival in patients undergoing resection of intrahepatic cholangiocarcinoma: Report of a Japanese nationwide survey

We reviewed the data of a nationwide follow‐up survey to determine the impact of hepatitis C virus (HCV) infection on the outcomes of hepatectomy for mass‐forming (MF) type, and combined mass‐forming

Cholangiocarcinoma in liver cirrhosis

Evaluation of cholangiocarcinoma in liver cirrhosis found no significant differences between HCC and CC in patients with and without prior history of chronic liver diseases.

Hepatitis C virus infection facilitates gallstone formation

Examination of the relationship between biliary diseases and hepatitis C virus infection found high prevalence of hepatitis C antibody is noted in patients with cholangiocarcinoma.

Double primary hepatic cancer (hepatocellular carcinoma and intrahepatic cholangiocarcinoma) in a single patient: A clinicopathologic study of 35 resected cases

The aim of this study is to report on the clinicopathological features and prognosis of patients with double hepatic cancer.

A case of cholangiocarcinoma detected in a patient with chronic hepatitis C after the elimination of HCV-RNA due to interferon therapy

Both close and long term obser-vations are required for patients who have achieved a sustained viral response of the hepatitis C virus after the elimination of HCV-RNA due to interferon therapy.

Hepatitis B Virus and Intrahepatic Cholangiocarcinoma

2 cases of ICC are reported that presented with a background of hepatitis B virus (HBV) infection and the possible pathophysiological relationships between ICC and HBV infection are discussed, with an emphasis on the x gene of HBV.

Increasing incidence of intrahepatic cholangiocarcinoma and its relationship to chronic viral hepatitis.

Despite well-known risk factors in the development of intrahepatic cholangiocarcinoma, recent reports focus on chronic hepatitis B and C viral infections because an increasing number of studies have observed an association.

Precursors of Cholangiocarcinoma

Many cases of cholangiocarcinoma are associated with prior biliary or hepatic disease, and the prevalence rate in patients with primary sclerosingCholangitis is 5–15%, with the cumulative risk of developing cholangsiocARCinoma being 1.5% per year.



Hepatitis C virus antibody in patients with primary liver cancer (hepatocellular carcinoma, cholangiocarcinoma, and combined hepatocellular‐cholangiocarcinoma) in Japan

The authors investigated the prevalence of anti‐HCV in HCC patients, as well as the same prevalence in patients with cholangiocarcinoma (CC) and combined hepatocellular–cholang iocarc inoma (combined HCC‐CC), to study the clinicopathologic features of anti-HCV–positive cases.

Surgical treatment of patients with mixed hepatocellular carcinoma and cholangiocarcinoma

The results of treatment of mixed hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) remain unclear because of the rarity of this disease.

Hepatitis C–associated hepatocellular carcinoma

A retrospective study to determine the prevalence of hepatitis C antibody in the sera of 59 patients with hepatocellular carcinoma who were HBsAg‐negative and had no evidence of alcoholic liver disease, primary biiary cirrhosis, autoimmune hepatitis, hemochromatosis or α1‐antitrypsin deficiency.

HCV-associated hepatocellular carcinoma without cirrhosis.

Cholangiocarcinoma as related to chronic intrahepatic cholangitis and hepatolithiasis. Case report and review of the literature.

The possible pathogenesis of cholangiocarcinomas is discussed and the importance of endoscopic retrograde cholANGiography in the diagnosis of this malignancy is emphasized.

Hepatitis C virus infection is associated with the development of hepatocellular carcinoma.

  • I. SaitoT. Miyamura Y. Ohta
  • Medicine, Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1990
There appears to be a strong association between HCV infection and the development of HCC, particularly in patients for which HBV infection cannot be implicated as a causative factor.

Possible contribution to hepatocarcinogenesis of X transcript of hepatitis B virus in japanese patients with hepatitis C virus

It is found that the HBx gene was expressed in many HCCs; the gene might promote hepatocarcinogenesis in patients with HCVAb and without HBsAg, but HGV is not closely related to hepatOCarcinogenic in such patients.

Risk factors for hepatocellular carcinoma among patients with chronic liver disease.

Patients with hepatitis C virus infection have a greatly increased risk of liver cancer.