Incidence of pneumonia in mechanically ventilated patients treated with sucralfate or cimetidine as prophylaxis for stress bleeding: bacterial colonization of the stomach.

@article{Kappstein1991IncidenceOP,
  title={Incidence of pneumonia in mechanically ventilated patients treated with sucralfate or cimetidine as prophylaxis for stress bleeding: bacterial colonization of the stomach.},
  author={Ines Kappstein and Gabi Schulgen and Th Friedrich and Petr Hellinger and Albert Benzing and Kathrin Geiger and Franz Dieter Daschner},
  journal={The American journal of medicine},
  year={1991},
  volume={91 2A},
  pages={
          125S-131S
        }
}
Retrograde colonization of the oropharynx from the stomach by microaspiration of gastric fluid is a recently recognized phenomenon associated with increased gastric pH that may result in pneumonia during ventilation therapy. In a prospective study we investigated 104 mechanically ventilated patients in the intensive care unit who were receiving sucralfate (n = 49) or cimetidine (n = 55) for stress ulcer prophylaxis. The incidence of pneumonia was 45.5% (25 patients) in the cimetidine group and… CONTINUE READING
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