Incidence of placental mosaicism leading to discrepant results between QF-PCR and karyotyping in 22,825 chorionic villus samples.

@article{Holgado2011IncidenceOP,
  title={Incidence of placental mosaicism leading to discrepant results between QF-PCR and karyotyping in 22,825 chorionic villus samples.},
  author={Elaine Holgado and Stuart Liddle and Terry Ballard and Lisa J Levett},
  journal={Prenatal diagnosis},
  year={2011},
  volume={31 11},
  pages={1029-38}
}
OBJECTIVE To review the frequency and analyse the origin of completely discrepant results observed between QF-PCR and karyotyping in chorionic villus samples (CVS) as a result of placental mosaicism. Also, to assess QF-PCR results for biallelic or triallelic patterns and determine their significance. METHODS Between May 2002 and December 2009, 22 825 CVS were received at TDL Genetics for processing by QF-PCR and karyotype. The QF-PCR and karyotype data were compared to determine the incidence… CONTINUE READING

From This Paper

Topics from this paper.

Similar Papers

Loading similar papers…