Incidence of osteoporosis and fragility fractures in asthma: a UK population-based matched cohort study

  title={Incidence of osteoporosis and fragility fractures in asthma: a UK population-based matched cohort study},
  author={Christos V. Chalitsios and Tricia M. McKeever and Dominick E. Shaw},
  journal={European Respiratory Journal},
Introduction Osteoporosis and fragility fractures are associated with corticosteroids which are the mainstay treatment for asthma; however, these bone comorbidities within asthma need to be better described. Methods A matched cohort study was conducted using the UK Clinical Practice Research Database (CPRD). Adults with an incident asthma code were identified and matched, with up to four randomly selected people without asthma, by age, sex and practice. Osteoporosis and fragility fracture… 
4 Citations

Risk of subtrochanteric and femoral shaft fractures due to bisphosphonate therapy in asthma: a population-based nested case–control study

To improve AFF prevention, early signs which may warrant imaging, such as prodromal thigh pain, should be discussed and regular review of bisphosphonates should occur in patients with asthma.

Hybrid fixation with ESIN for both bone forearm fractures in adults: A case report and literature review

The hybrid fixation of ESIN and plate is an effective option for both bone forearm fractures in adults.

STAT3 activation by catalpol promotes osteogenesis-angiogenesis coupling, thus accelerating osteoporotic bone repair

The data showed that catalpol could promote osteogenic ability of BMSC and B MSC-dependent angiogenesis through activation of the JAK2/STAT3 axis, suggesting it may be an ideal therapeutic agent for clinical medication of osteoporotic bone fracture.



Long-term fracture risk following adult-onset asthma: a population-based study

A 70% increase in overall fracture risk among unselected community patients with adult onset asthma was mainly confined to the subset who also had chronic obstructive pulmonary disease and was influenced by substantial corticosteroid use.

Use of Oral Corticosteroids and Risk of Fractures

The results quantify the increased fracture risk during oral corticosteroid therapy, with greater effects on the hip and spine than forearm, which has implications for the use of preventative agents against bone loss in patients at highest risk.

Vertebral fractures in steroid dependent asthma and involutional osteoporosis: a comparative study.

Vertebral fractures occur in patients treated with steroids in the presence of higher bone mineral density than is the case with patients with involutional osteoporosis, suggesting that the assessment of the efficacy of preventive treatment requires measurement of bone mineraldensity and radiology.

Screening and treatment of osteoporosis after hip fracture: comparison of sex and race.

Osteoporosis in the European Union: a compendium of country-specific reports

In spite of the high cost of osteoporosis, a substantial treatment gap and projected increase of the economic burden driven by aging populations, the use of pharmacological prevention of osteeporosis has decreased in recent years, suggesting that a change in healthcare policy concerning the disease is warranted.

Bone mineral density in perimenopausal women with asthma: a population-based cross-sectional study.

Although BMDs were not significantly decreased in the asthmatics who had used inhaled corticosteroids, the duration of use correlated negatively with spinal BMD and was also associated with spinalBMD in multiple regression analysis.

Use of Inhaled Corticosteroids and Risk of Fractures

  • T. van StaaH. LeufkensC. Cooper
  • Medicine
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2000
It is concluded that users of inhaled corticosteroids have an increased risk of fracture, particularly at the hip and spine, however, this excess risk may be related more to the underlying respiratory disease than to inhaled Corticosteroid.

Use of inhaled corticosteroids and the risk of fracture.

New approach in which data on people with airflow obstruction from a large Medical Research Council study of the assessment and management of older people in the community with longitudinal data from their computerized general practice records provides further evidence that inhaled corticosteroid use is an independent risk factor for fracture.

The impact of oral corticosteroid use on bone mineral density and vertebral fracture.

In patients taking long-term oral corticosteroids for chronic lung disease, the relationship between vertebral fracture risk and BMD is similar to that seen in other populations.

Mortality after osteoporotic fractures

The risk of death is increased in patients with osteoporotic fractures and that the highest risk is found immediately after the fracture event, with a decrease in deaths causally related to the fracture.