Incidence of osteonecrosis of the jaw in women with postmenopausal osteoporosis in the health outcomes and reduced incidence with zoledronic acid once yearly pivotal fracture trial.

  title={Incidence of osteonecrosis of the jaw in women with postmenopausal osteoporosis in the health outcomes and reduced incidence with zoledronic acid once yearly pivotal fracture trial.},
  author={John T Grbic and Regina Landesberg and Shou-qing Lin and Peter Mesenbrink and Ian R. Reid and Ping Chung Leung and Noem{\'i} Casas and Chris Recknor and Ye Hua and Pierre Dominique Delmas and Erik Fink Eriksen},
  journal={Journal of the American Dental Association},
  volume={139 1},
BACKGROUND The authors determined incidence of osteonecrosis of the jaw (ONJ) in a large, prospective three-year clinical trial of zoledronic acid in women with postmenopausal osteoporosis (PMO). METHODS A total of 7,714 women with PMO received intravenous zoledronic acid 5 mg or a placebo. No spontaneous reports of ONJ were received. An independent, blinded adjudication committee searched the trial's adverse event database by using 60 terms. On an ongoing basis, the committee reviewed the… 

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