Incidence of neutropenia during treatment of bone-related infections with piperacillin-tazobactam.

@article{Peralta2003IncidenceON,
  title={Incidence of neutropenia during treatment of bone-related infections with piperacillin-tazobactam.},
  author={Felipe Peralta and Manuel Ben{\'i}tez S{\'a}nchez and Mar{\'i}a P{\'i}a Roiz and Mar{\'i}a A. Pe{\~n}a and Miguel A. Tejero and Rafael Arjona},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2003},
  volume={37 11},
  pages={1568-72}
}
Of 41 patients with bone-related infections who were treated for > or =10 days with piperacillin-tazobactam, 14 (34%) developed neutropenia. Cumulative doses of piperacillin administered to neutropenic patients were higher than those administered to nonneutropenic ones (330 vs. 237 g; P=.008), and an inverse correlation was detected between the absolute neutrophil count at the end of treatment and the cumulative dose of piperacillin (r=-0.47, P=.002). Moreover, the incidence of piperacillin… CONTINUE READING
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