Incidence of late rectal bleeding in high-dose conformal radiotherapy of prostate cancer using equivalent uniform dose-based and dose-volume-based normal tissue complication probability models.

@article{Soehn2007IncidenceOL,
  title={Incidence of late rectal bleeding in high-dose conformal radiotherapy of prostate cancer using equivalent uniform dose-based and dose-volume-based normal tissue complication probability models.},
  author={Matthias Soehn and D i Yan and Jian Liang and Elisa Meldolesi and Carlos Vargas and M. Alber},
  journal={International journal of radiation oncology, biology, physics},
  year={2007},
  volume={67 4},
  pages={1066-73}
}
PURPOSE Accurate modeling of rectal complications based on dose-volume histogram (DVH) data are necessary to allow safe dose escalation in radiotherapy of prostate cancer. We applied different equivalent uniform dose (EUD)-based and dose-volume-based normal tissue complication probability (NTCP) models to rectal wall DVHs and follow-up data for 319 prostate cancer patients to identify the dosimetric factors most predictive for Grade > or = 2 rectal bleeding. METHODS AND MATERIALS Data for 319… CONTINUE READING