• DOI:10.1097/PCC.0B013e318166870e
• Corpus ID: 9927553

Incidence of hypo- and hypercarbia in severe traumatic brain injury before and after 2003 pediatric guidelines*

@article{Curry2008IncidenceOH,
  title={Incidence of hypo- and hypercarbia in severe traumatic brain injury before and after 2003 pediatric guidelines*},
  author={Rebecca Lee Curry and William Hollingworth and Richard G. Ellenbogen and Monica S. Vavilala},
  journal={Pediatric Critical Care Medicine},
  year={2008},
  volume={9},
  pages={141-146}
}

• R. Curry, W. Hollingworth, +1 author M. Vavilala
• Published 1 March 2008
• Medicine
• Pediatric Critical Care Medicine

Objective: To examine the incidence of severe hypocarbia (Paco2 <30 mm Hg) in patients with severe pediatric traumatic brain injury before and after publication of the 2003 pediatric guidelines (PG). Design: Retrospective cohort analysis. Setting: Harborview Medical Center, Seattle, Washington (January 1, 1995, to December 31, 2005). Patients: Children <15 yrs of age with severe pediatric traumatic brain injury. Interventions: None. Measurements and Main Results: The pre-PG group (before August 1, 2003) included 375 patients and the post-PG group included 89 patients. Post PG guidelines, there was a trend toward earlier (45 vs. 32 mins; p = .05) and more frequent (7.1 vs. 8.4 samples; p = .06) Paco2 sampling within 48 hrs of admission. Children 0–2 yrs had a longer time (75.0 mins) between admission and first Paco2 sample than older children (44.3 mins; p < .01). The youngest children also had the highest incidence of severe hypocarbia on the first Paco2 sample (31% vs. 19%; p = .02). Incidence of severe hypocarbia was high and did not decline (60% vs. 52%; p = .2) after the PG guidelines. However, over the 11 yrs, the odds of severe hypocarbia decreased (adjusted odds ratio 0.9; 95% confidence interval 0.84–0.96). During both periods, the incidence of severe hypocarbia was highest during the first 2 hrs after hospital admission. Intracranial pressure monitors were used more frequently post-PG. In 62 of 82 (77%) patients with severe hypocarbia in whom an intracranial pressure monitor was in place, the preceding intracranial pressure was <20 mm Hg. Severe hypocarbia independently predicted inpatient mortality (adjusted odds ratio 2.8; 95% confidence interval 1.3–5.9). Conclusions: Although Paco2 sampling was more frequent during the post-PG period and severe hypocarbia decreased during successive study years, the incidence of severe hypocarbia remained high during the first 48 hrs after hospital admission during the post-PG period. Time to Paco2 sampling was longer in young children and associated with more severe hypocarbia. The presence of severe hypocarbia predicted mortality.