Incidence of chromosome 18 disomy in human sperm nuclei as detected by nonisotopic in situ hybridization

@article{Guttenbach1994IncidenceOC,
  title={Incidence of chromosome 18 disomy in human sperm nuclei as detected by nonisotopic in situ hybridization},
  author={Martina Guttenbach and Renate Schakowski and Michael Schmid},
  journal={Human Genetics},
  year={1994},
  volume={93},
  pages={421-423}
}
Nonradioactive in situ hybridization with an α-satellite DNA probe specific for chromosome 18 was performed on human interphase sperm nuclei to detect the frequency of sperm cells disomic for chromosome 18. A total of 16127 sperm heads from eight healthy donors, aged 23–57 years, was investigated, and a minimum of 2000 sperm nuclei per proband was analyzed. The disomy rate ranged from 0.25% to 0.5%, with an average of 0.36%. This frequency does not differ significantly from that determined for… CONTINUE READING
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Estimation of aneuploidy levels in human spermatozoa using chromosome complements and chromosome specific probes

  • C Jackson-Cook, VL Hailer
  • Am J Hum Genet
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