Incidence of adverse drug events in an academic hospital: a prospective cohort study.

@article{Aljadhey2013IncidenceOA,
  title={Incidence of adverse drug events in an academic hospital: a prospective cohort study.},
  author={Hisham Aljadhey and Mansour Adam Mahmoud and Ahmed Y Mayet and Mashael K. Alshaikh and Yusuf Mohammed Ahmed and Michael D. Murray and D. Bates},
  journal={International journal for quality in health care : journal of the International Society for Quality in Health Care},
  year={2013},
  volume={25 6},
  pages={
          648-55
        }
}
  • H. Aljadhey, M. Mahmoud, +4 authors D. Bates
  • Published 1 December 2013
  • Medicine
  • International journal for quality in health care : journal of the International Society for Quality in Health Care
OBJECTIVE To determine the incidence of adverse drug events (ADEs) and assess their severity and preventability. DESIGN A prospective cohort study. SETTING A 900-bed tertiary academic hospital. PARTICIPANTS A total of 977 patients admitted to two medical, one surgical and two intensive care units over four months. MAIN OUTCOME MEASURES The primary outcomes were the incidence of ADEs, preventability of ADEs, potential ADEs and medication errors. A physician and a clinical pharmacist… 
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56 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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56 Citations

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Citation Type

A multicenter record review of in-hospital adverse drug events requiring a higher level of care
TLDR
The high number of pADE with patient harm shows that there is a need for structural improvement of pharmacotherapeutic care, and detection of these pADEs can be the basis for the implementation of these improvements.
Incidence of adverse drug events in public and private hospitals in Riyadh, Saudi Arabia: the (ADESA) prospective cohort study
TLDR
It was found that ADEs were common in Saudi hospitals, especially in ICUs, causing significant morbidity and mortality, and future studies should focus on investigating the root causes at the prescribing stage, and development and testing of interventions to minimise harm from medications.
Potential adverse drug events and its predictors among hospitalized patients at medical center in Ethiopia: a prospective observational study
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The incidence, contributing factors, predictors, severity, and preventability of PADEs among hospitalized adult patients at Jimma Medical Center, Ethiopia, and Elixhauser comorbidity Index were assessed to identify factors predicting PADE occurrence.
Influence of adverse drug events on morbidity and mortality in intensive care units: the JADE study.
TLDR
ADEs were common in ICUs and significantly associated with longer length of ICU stay but did not influence on mortality, while mortality was not affected even after adjusting for patients' severity of illness.
Preventability analysis of adverse drug reactions in a Jordanian hospital: a prospective observational study
TLDR
A high proportion of the identified adverse drug reactions were found to be preventable, and insufficient monitoring and inappropriate dosing were the most important factors associated with preventable adversedrug reactions.
An individual patient data meta-analysis on factors associated with adverse drug events in surgical and non-surgical inpatients.
TLDR
Efficiency in prevention of ADEs may be improved by targeted vigilance systems for alertness of physicians and pharmacists.
Mortality among patients due to adverse drug reactions that occur following hospitalisation: a meta-analysis
TLDR
The heterogeneity (I2) in its estimation based on study design, study population and data collection methods was explored and age groups and study wards have important influence on prevalence of fatal ADRIn and its heterogeneity across studies.
Incidence of drug interactions in intensive care units in tertiary care settings: Classification, facts and measures.
TLDR
Despite the facts regarding patient safety and minimizing DIs error, polypharmacy is still frequent in critically ill patients admitted in ICU attributed high risk of adverse reactions due to use of multiple interventions to treat severity of disease condition.
Incidence, causes, and consequences of preventable adverse drug reactions occurring in inpatients: A systematic review of systematic reviews
TLDR
High methodological and statistical heterogeneity across primary studies evaluating adverse drug events reduces the validity of the overall PADR incidence derived from the meta-analyses of the pooled data.
Antimicrobial-related medication safety incidents: a regional retrospective study in West of Scotland hospitals.
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