Incidence of Candida in psoriasis – a study on the fungal flora of psoriatic patients

  title={Incidence of Candida in psoriasis – a study on the fungal flora of psoriatic patients},
  author={Arie Waldman and Amos Gilhar and Lea Duek and Israela Berdicevsky},
Summary.  The presence of Candida albicans and other Candida species in saliva and faeces of 50 psoriatic patients compared with a control group of 50 healthy donors was examined quantitatively. The quantity of Candida in saliva and faeces of the psoriatics proved to be significantly higher than in the controls. Candida was detected in 78% of the saliva samples of the psoriatics but in only 50% of the controls, and in the faeces samples in 72% of the psoriatics, but in only 46% of the controls… 

Prevalence of Candida in saliva and skin lesions of Psoriasis Vulgaris patients

Oral Candidiasis can be observed more commonly in Psoriatic patients compared to normal ones and the severity of candida between case and control groups was statistically significant (P<0.05).

Prevalence of Candida on the tongue and intertriginous areas of psoriatic and atopic dermatitis patients

The Candida of the tongue was asymptomatic and did not correlate with age, gender, type of psoriasis or severity of the disease, therefore it is concluded that this is clinically irrelevant.

Oral Candida colonization and plaque type psoriasis: Is there any relationship?

The prevalence of oral candidiasis is higher in psoriatic patients and is associated with disease severity, and there was a positive correlation between psoriasis severity and colony count.

Prevalence of Candida Species in Patients with Psoriasis.

Mycological analysis of skin samples in patients of the clinical group with PP and PI showed a statistically significant difference as well as correlation between the results of isolated specimens of Candida species from the skin of intertriginous areas and Psoriasis lesions, the clinical form of psoriasis, and the PASI score.

The Comparison of Candida spp. Colonization on Psoriasis Vulgaris Patient and Control

No significant difference between sex, age, period of complaints, age onset, degree of severity (Psoriasis Area and Severity Index), and therapy history, with positive culture of Candida spp.

Prevalence and Possible Role of Candida Species in Patients with Psoriasis: A Systematic Review and Meta-Analysis

It is found Candida species detection rates for psoriatics were significantly higher than those in the controls, especially in the oral mucosa milieux, suggesting psoriasis may be one of the systemic diseases that predispose to oral Candida spp.

Oral Candida colonization and candidiasis in patients with psoriasis.

Fungal Infections among Psoriatic Patients: Etiologic Agents, Comorbidities, and Vulnerable Population

It is suggested that fungal pathogens, particularly dermatophytes, may play an important role in the pathogenicity of psoriasis and concomitant use of anti-inflammatory drugs and antifungals may represent an effective therapeutic approach for better management of chronic lesions among these patients.

The role of candida albicans in the pathogenesis of psoriasis vulgaris: a systematic literature review

Studies show that C. albicans, opportunistic yeast, like diploid fungus, may be involved in the pathogenesis of psoriasis.

Characterization of Oral and Gut Microbiota in Patients with Psoriatic Diseases: A Systematic Review.

The role of the microbiota in patients with psoriasis requires further investigation using more robust methods, and probiotics were associated with a significant improvement in the severity of Psoriasis, but did not change microbiota.



Fungal Flora of Human Faeces in Psoriasis and Atopic Dermatitis

Faeces samples taken from 343 patients with psoriasis and 581 patients with atopic dermatitis were subjected to mycological examination and revealed a predominance of Candida albicans and non‐pathogenic yeasts.

Studies on the Yeast Flora in Patients Suffering from Psoriasis Capillitii or Seborrhoic Dermatitis of the Scalp

In 65 patients with scalp psoriasis or seborrhoic dermatitis of the scalp, stool specimens, tongue swabs and scalp scales were examined for yeasts. The stool specimens showed in 70.8% of the patient

Oral nystatin in the treatment of psoriasis.

Improvement in the condition of patients with both psoriasis and inflammatory bowel disease when treated with oral nystatin is reported, suggesting the possibility that ketoconazole was working systemically, perhaps on yeasts residing in the gut.

[The significance of yeasts in seborrheic eczema].

Recent clinical and experimental data favor the role of intestinal candidiasis in seborrheic dermatitis: a high quantity of Candida in the feces of the affected patients, elevated phospholipase activity of the Candida sp.

Microbial factors in psoriasis.

The results reported by Belew et al 7 and Skinner et al 8 now afford enough support to propose the following hypothesis, that the presence of a large quantity of Malassezia ovalis in so-called seborrheic locations would be adequate to provoke a psoriatic reaction in susceptible persons.

Improvement of psoriasis of the scalp with ketoconazole.

If M ovalis were indeed evoking the development of psoriatic disease of the scalp, it should be possible to treat psoriasis of the forehead successfully with nothing but oral ketoconazole.

Clinical analysis of staphylococcal superantigen hyper-reactive patients with psoriasis vulgaris.

The results raise the possibility that monocytes, as well as T cells, are markedly activated by staphylococcal superantigen in patients with psoriasis vulgaris, which may play a role in the triggering or aggravating of Psoriasis mediated by secreted cytokines.

A potential role for superantigens in the pathogenesis of psoriasis.

The hypothesis that local activation of cutaneous T cells in psoriasis may be caused by a superantigen is supported and provides a new direction for investigating the pathogenesis of this complex and fascinating skin disorder.

Evidence for a streptococcal superantigen-driven process in acute guttate psoriasis.

Recent studies have suggested that T cells play a critical role in the pathogenesis of psoriasis. Guttate psoriasis is a well-defined form of psoriasis frequently associated with streptococcal throat

Superantigen Production by Staphylococcus aureus in Psoriasis

It is believed that superantigens are not essential in sustaining disease activity but may, instead, be exacerbating or triggering factors for some psoriasis patients.