Incidence of -93 MLH1 promoter polymorphism in familial and sporadic colorectal cancer.

@article{MartnezUruea2013IncidenceO,
  title={Incidence of -93 MLH1 promoter polymorphism in familial and sporadic colorectal cancer.},
  author={Noelia Mart{\'i}nez-Urue{\~n}a and Laura Graciela Ch{\'a}vez Mac{\'i}as and Luc{\'i}a P{\'e}rez-Cabornero and Maurizio Valentino Infante and Enrique Lastra and Juan Jes{\'u}s Cruz and Cristina Miner and Roberto {\'A}lvarez Gonz{\'a}lez and M{\"u}zeyyen Duran},
  journal={Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland},
  year={2013},
  volume={15 3},
  pages={
          e118-23
        }
}
AIM The MLH1 promoter contains a common single nucleotide polymorphism (-93 guanine > adenine) located in an essential region for maximum transcriptional activity. This has been associated with an increased risk of microsatellite instability (MSI) colorectal cancer. The aim of the study was to compare the distribution of MLH1 -93G>A genotypes between patients with familial colon cancer, sporadic colon cancer and healthy subjects. METHOD We genotyped 200 familial colon samples, 183 cases of… CONTINUE READING
BETA

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