Incidence and risk factors of oral antibiotic-associated diarrhea in an outpatient pediatric population.

Abstract

BACKGROUND Little information is available on the epidemiologic characteristics of antibiotic-associated diarrhea (AAD) in children. The authors' aim was to evaluate the incidence of AAD in an outpatient pediatric population and to identify risk factors. METHODS Children aged 1 month to 15.4 years treated with oral antibiotics for a proven or suspected infection were enrolled from an ambulatory pediatric practice during an 11-month period. Parents recorded the daily frequency and characteristics of stools using a diary during the antibiotic treatment and for 1 week after it was stopped. An episode of diarrhea was defined by at least 3 soft or liquid stools/d for at least 2 consecutive days. Risk factors for AAD-age, type of antibiotic treatment, type of combined treatment, and site of infection-were analyzed. RESULTS Of 650 children included, 11% had an episode of AAD, lasting a mean of 4.0 +/- 3.0 days, beginning a mean of 5.3 +/- 3.5 days after the start of antibiotic treatment. No child was hospitalized because of AAD. The incidence of AAD was higher in children less than 2 years (18%) than in those more than 2 years (3%; P < 0.0001). The incidence of AAD was particularly high after administration of certain antibiotics (amoxicillin/clavulanate, 23%; P = 0.003 compared with other antibiotics). The type of combined treatment and site of infection did not influence the onset of AAD. CONCLUSIONS Antibiotic-associated diarrhea was common in these outpatient children, especially for those aged less than 2 years and after the prescription of certain antibiotics, particularly, the combination of amoxicillin/clavulanate.

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@article{Turck2003IncidenceAR, title={Incidence and risk factors of oral antibiotic-associated diarrhea in an outpatient pediatric population.}, author={Dominique Turck and J P Bernet and Jacques Marx and H{\'e}l{\`e}ne Kempf and Patrick Giard and Olivier Walbaum and Andr{\'e} Lacombe and Françoise Rembert and Francis Toursel and P. Bernasconi and Fr{\'e}d{\'e}ric Gottrand and Lynne Vernice McFarland and Karine Bloch}, journal={Journal of pediatric gastroenterology and nutrition}, year={2003}, volume={37 1}, pages={22-6} }