Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy

@article{Shelburne2005IncidenceAR,
  title={Incidence and risk factors for immune reconstitution inflammatory syndrome during highly active antiretroviral therapy},
  author={Samuel A. Shelburne and Fehmida Visnegarwala and Jorge G Darcourt and Edward A. Graviss and Thomas P. Giordano and A Clinton White and Richard J. Hamill},
  journal={AIDS},
  year={2005},
  volume={19},
  pages={399–406}
}
Background:There is little systematic information regarding the immune reconstitution inflammatory syndrome (IRIS). Objective:To determine the incidence, risk factors, and long-term outcome of IRIS in HIV-infected patients receiving highly active antiretroviral therapy (HAART) who were coinfected with one of three common opportunistic pathogens. Design:A retrospective cohort identified through a city-wide prospective surveillance program. Methods:A retrospective chart review was performed for… 

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IRIS occurred in 20% of HIV-infected children starting HAART in Peru and was associated with more advanced disease and malnutrition and future research is needed to examine specific risk factors associated with pediatric IRIS.
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