Incidence and prognostic impact of FoxP3+ regulatory T cells in human gliomas.

  title={Incidence and prognostic impact of FoxP3+ regulatory T cells in human gliomas.},
  author={Amy Heimberger and Mohamed K. Abou-Ghazal and Chantal Reina-Ortiz and David S. Yang and Wei Sun and Wei Qiao and Nobuyoshi Hiraoka and Gregory N Fuller},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={14 16},
PURPOSE The incidence of regulatory T cells (Treg) in intrinsic central nervous system malignancies is unknown. Immunotherapeutic approaches that inhibit the Treg population may be limited to a subset of patients with gliomas. Our hypothesis is that only the most malignant gliomas have a prominent glioma-infiltrating Treg population that contributes to the immunosuppressive biology and that the presence of Tregs is a negative prognostic variable. EXPERIMENTAL DESIGN We measured the incidence… CONTINUE READING
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