Incidence and physiological relevance of protein thiol switches.

  title={Incidence and physiological relevance of protein thiol switches.},
  author={Lars Ingo Ole Leichert and Tobias P Dick},
  journal={Biological chemistry},
  volume={396 5},
A few small-molecule oxidants, most notably hydrogen peroxide, can act as messengers in signal transduction. They trigger so-called 'thiol switches', cysteine residues that are reversibly oxidized to transiently change the functional properties of their host proteins. The proteome-wide identification of functionally relevant 'thiol switches' is of significant interest. Unfortunately, prediction of redox-active cysteine residues on the basis of surface accessibility and other computational… CONTINUE READING

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