Incidence and outcomes of acute lung injury.

@article{Rubenfeld2005IncidenceAO,
  title={Incidence and outcomes of acute lung injury.},
  author={Gordon David Rubenfeld and Ellen Caldwell and Eva Horn Peabody and Jim Weaver and Diane P. Martin and Margaret J. Neff and Eric J. Stern and Leonard D. Hudson},
  journal={The New England journal of medicine},
  year={2005},
  volume={353 16},
  pages={
          1685-93
        }
}
BACKGROUND Acute lung injury is a critical illness syndrome consisting of acute hypoxemic respiratory failure with bilateral pulmonary infiltrates that are not attributed to left atrial hypertension. Despite recent advances in our understanding of the mechanism and treatment of acute lung injury, its incidence and outcomes in the United States have been unclear. METHODS We conducted a prospective, population-based, cohort study in 21 hospitals in and around King County, Washington, from April… 

Figures and Tables from this paper

Incidence and Outcomes of Pediatric Acute Lung Injury

The first population-based estimate of pediatric acute lung injury incidence in the United States is presented, finding that population incidence and mortality rates are lower than those for adult acute lungs injury.

Incidence and risk factors of recurrent acute lung injury*

Gastroesophageal reflux disease was identified as an important risk factor for recurrent acute lung injury and may suggest an important role of gastric aspiration in the development of this syndrome.

Impact of acute lung injury and acute respiratory distress syndrome after traumatic brain injury in the United States.

BACKGROUND Traumatic brain injury (TBI) is a major cause of disability, morbidity, and mortality. The effect of the acute respiratory distress syndrome and acute lung injury (ARDS/ALI) on in-hospital

Long-term Outcomes After Acute Lung Injury/Acute Respiratory Distress Syndrome

The pathophysiology of ALI involves capillary leak resulting in accumulation of protein-rich exudate in the interstitium and alveolar spaces, which impairs gas exchange, contributing to atelectasis and dead space.

Predictors of early acute lung injury at a combat support hospital: a prospective observational study.

It is determined that the presence of pulmonary injury had the greatest impact on the incidence of early ALI, and there was also an independent relationship between the amount of FFP transfused andThe incidence ofEarly ALI.

Predicting mortality in patients with acute lung injury.

  • G. BudingerK. Walley
  • Medicine, Biology
    American journal of respiratory and critical care medicine
  • 2011
The levels of soluble LRP-1 (sL RP-1) were increased in patients with ARDS compared with a control group of spontaneously breathing subjects or mechanically ventilated patients with cardiogenic pulmonary edema and the BAL levels of sLRP- 1 were positively correlated with APACHE II scores and were significantly higher in patients who died from AR DS compared with those who survived.

Acute Lung Injury in the Acute Care Surgery Patient

Factors increasing a patient’s likelihood of developing ALI are those that predispose a patient to massive inflammation, as well as increasing age, preexisting need for mechanical ventilation, smoke inhalation, massive transfusion, and drug overdose.

Acute lung injury: epidemiology, pathogenesis, and treatment.

Phase III clinical trials by the NHLBI ARDS Network have resulted in improvement in survival and a reduction in the duration of mechanical ventilation with a lung-protective ventilation strategy and fluid conservative protocol, potential areas of future treatments include nutritional strategies, statin therapy, and mesenchymal stem cells.

Prevalence of acute lung injury among medical patients in the emergency department.

The prevalence of ALI was nearly 9% in adult nontrauma patients receiving mechanical ventilation in the ED, and further study is required to determine which types of patients present to the ED with ALI, the extent to which lung protective ventilation is used, and the need for ED ventilator management algorithms.

Acute Lung Injury And Acute Respiratory Distress Syndrome: A Review Article

Evidence supports use of low tidal volume ventilatory settings and conservative intravenous fluid strategies, but long term outcomes are related to neuromuscular, cognitive and psychological issues rather than pulmonary, and rehabilitation during recovery needs to focus on this.
...

References

SHOWING 1-10 OF 30 REFERENCES

Incidence of acute lung injury in the United States.

Based on this analysis, which used prospective clinical trial screening data and conservative assumptions about where patients with ALI are cared for, the incidence of ALI in the United States appears to be higher than previously reported.

Incidence and mortality of acute lung injury and the acute respiratory distress syndrome in three Australian States.

Although the incidences of ALI and ARDS are higher and the mortality rates are lower than those reported from studies in other countries, multicenter international studies are required to exclude methodological differences as the cause for this finding.

Incidence and Mortality after Acute Respiratory Failure and Acute Respiratory Distress Syndrome in Sweden, Denmark, and Iceland

To determine the incidence and 90-d mortality of acute respiratory failure (ARF), acute lung injury (ALI), and the acute respiratory distress syndrome (ARDS), we carried out an 8-wk prospective

Incidence, severity, and mortality of acute respiratory failure in Berlin, Germany.

The data offer novel information on incidence, severity, and mortality of ARF in a major urban population in Berlin, Germany, a metropolis with a population of 3.44 million.

High values of the pulmonary artery wedge pressure in patients with acute lung injury and acute respiratory distress syndrome

Mandating a PAWP of 18 mmHg or less may negatively impact clinical trials in which ARDS is an inclusion/exclusion criteria or an endpoint, as well as in this group of patients with ALI/ARDS, which is common.

Pulmonary dead-space fraction as a risk factor for death in the acute respiratory distress syndrome.

Increased dead-space fraction is a feature of the early phase of the acute respiratory distress syndrome and Elevated values are associated with an increased risk of death.

One-year outcomes in survivors of the acute respiratory distress syndrome.

The absence of systemic corticosteroid treatment, the absence of illness acquired during the intensive care unit stay, and rapid resolution of lung injury and multiorgan dysfunction were associated with better functional status during the one-year follow-up.

Clinical risks for development of the acute respiratory distress syndrome.

Primary factors associated with increased risk for ARDS in clinical risk subgroups include an elevated Acute Physiologic and Chronic Health Evaluation II (APACHE II) score in patients with sepsis and increased APACHEII and Injury Severity Scores (ISS) in trauma victims.

Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care

Severe sepsis is a common, expensive, and frequently fatal condition, with as many deaths annually as those from acute myocardial infarction, and is especially common in the elderly and is likely to increase substantially as the U.S. population ages.

Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome.

As compared with conventional ventilation, the protective strategy was associated with improved survival at 28 days, a higher rate of weaning from mechanical ventilation, and a lower rate of barotrauma in patients with the acute respiratory distress syndrome.