Incidence and clinicobiologic characteristics of leukemic B-cell chronic lymphoproliferative disorders with more than one B-cell clone.

@article{Snchez2003IncidenceAC,
  title={Incidence and clinicobiologic characteristics of leukemic B-cell chronic lymphoproliferative disorders with more than one B-cell clone.},
  author={M A S{\'a}nchez and Julia Almeida and David Gonz{\'a}lez and Marcos Gonzalez and Maria-Antonia Garcia-Marcos and Ana Balanzategui and Mar{\'i}a-Consuelo L{\'o}pez-Berges and Josep Nomdedeu and Teresa Vallesp{\'i} and M. Barbon and Alejandro Mart{\'i}n and Pilar Mart{\'i}n de la Fuente and Guillermo Mart{\'i}n-N{\'u}{\~n}ez and Javier Fern{\'a}ndez-Calvo and J Hern{\'a}ndez and Jes{\'u}s Fernando San Miguel and Alberto Orfao},
  journal={Blood},
  year={2003},
  volume={102 8},
  pages={2994-3002}
}
Leukemic B-chronic lymphoproliferative disorders (B-CLPDs) are generally believed to derive from a monoclonal B cell; biclonality has only occasionally been reported. In this study, we have explored the incidence of B-CLPD cases with 2 or more B-cell clones and established both the phenotypic differences between the coexisting clones and the clinicobiologic features of these patients. In total, 53 B-CLPD cases with 2 or more B-cell clones were studied. Presence of 2 or more B-cell clones was… CONTINUE READING
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PCR-based clonality studies for early diagnosis of lymphoproliferative disorders: report of the BIOMED-2 concerted action [abstract

  • JM van Dongen, AW Langerak, JF San Miguel
  • Blood
  • 2001

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