Incidence and clinical significance of hepatitis B virus precore gene translation initiation mutations in e antigen‐negative patients

@article{Laras1998IncidenceAC,
  title={Incidence and clinical significance of hepatitis B virus precore gene translation initiation mutations in e antigen‐negative patients},
  author={A. Laras and J. Koskinas and K. Avgidis and S. Hadziyannis},
  journal={Journal of Viral Hepatitis},
  year={1998},
  volume={5}
}
  • A. Laras, J. Koskinas, +1 author S. Hadziyannis
  • Published 1998
  • Medicine
  • Journal of Viral Hepatitis
  • Hepatitis Be antigen (HBeAg)‐negative chronic hepatitis B (CHB) is associated with hepatitis B virus (HBV) variants harbouring changes in the precore region. Most commonly, a G to A point mutation at nucleotide 1896 (m1896) creates a novel translation stop codon that prevents HBeAg production. In the Mediterranean region the m1896 mutation prevails in greater than 98% of HBeAg‐negative CHB patients. In this study the prevalence of additional mutations in the precore region was investigated… CONTINUE READING
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    References

    SHOWING 1-10 OF 33 REFERENCES
    Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis.
    • M. Brunetto, M. Giarin, +7 authors H. Will
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 1991
    • 358
    • PDF
    A new hepatitis B virus strain in patients with severe anti-HBe positive chronic hepatitis B.
    • 222