Incidence and clinical significance of hepatitis B virus precore gene translation initiation mutations in e antigen-negative patients.

@article{Laras1998IncidenceAC,
  title={Incidence and clinical significance of hepatitis B virus precore gene translation initiation mutations in e antigen-negative patients.},
  author={Andreas Laras and John Koskinas and K Avgidis and Stephanos J. Hadziyannis},
  journal={Journal of viral hepatitis},
  year={1998},
  volume={5 4},
  pages={
          241-8
        }
}
Hepatitis Be antigen (HBeAg)-negative chronic hepatitis B (CHB) is associated with hepatitis B virus (HBV) variants harbouring changes in the precore region. Most commonly, a G to A point mutation at nucleotide 1896 (m1896) creates a novel translation stop codon that prevents HBeAg production. In the Mediterranean region the m1896 mutation prevails in greater than 98% of HBeAg-negative CHB patients. In this study the prevalence of additional mutations in the precore region was investigated… CONTINUE READING

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