Incidence and clinical implications of ATM aberrations in chronic lymphocytic leukemia.

@article{Ouillette2012IncidenceAC,
  title={Incidence and clinical implications of ATM aberrations in chronic lymphocytic leukemia.},
  author={Peter D Ouillette and Jinghui Li and Rita Shaknovich and Yifeng Li and Ari Melnick and Kerby Shedden and S. Nur Hidayah Malek},
  journal={Genes, chromosomes & cancer},
  year={2012},
  volume={51 12},
  pages={1125-32}
}
A subset of chronic lymphocytic leukemia (CLL) carries mutations in ataxia telangiectasia mutated (ATM). Such ATM mutations may be particularly relevant in the setting of del11q, which invariably results in the deletion of one ATM allele. To improve our understanding of the frequency and type of ATM mutations that exist in CLL, we resequenced all ATM coding exons in 24 CLL with del11q using direct sequencing. We detected two missense mutations, resulting in an ATM mutation frequency of 8… CONTINUE READING
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