Incidence, characterization, and clinical impact analysis of peginterferon beta1a immunogenicity in patients with multiple sclerosis in the ADVANCE trial.

@article{White2016IncidenceCA,
  title={Incidence, characterization, and clinical impact analysis of peginterferon beta1a immunogenicity in patients with multiple sclerosis in the ADVANCE trial.},
  author={Joleen T. White and Scott D. Newsome and Bernd C. Kieseier and Robert Bermel and Yue Cui and Ali Seddighzadeh and Serena Hung and Mary Claire Crossman and M. Madhusudana Subramanyam},
  journal={Therapeutic advances in neurological disorders},
  year={2016},
  volume={9 4},
  pages={239-49}
}
BACKGROUND Efficacy of interferon beta in multiple sclerosis (MS) can be dampened in patients who develop neutralizing antidrug antibodies (NAbs). Peginterferon beta1a is an interferon conjugated with a polyethylene glycol (PEG) moiety. Pegylation increases a drug's half life and exposure, and may also reduce immunogenicity. OBJECTIVE The objective of this study was to characterize the incidence and impact of immunogenicity to peginterferon beta1a over 2 years in patients with MS. METHODS… CONTINUE READING
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