Incensole acetate reduces depressive-like behavior and modulates hippocampal BDNF and CRF expression of submissive animals

@article{Moussaieff2012IncensoleAR,
  title={Incensole acetate reduces depressive-like behavior and modulates hippocampal BDNF and CRF expression of submissive animals},
  author={A. Moussaieff and M. Gross and Elimelech Nesher and Tatiana Tikhonov and G. Yadid and A. Pinhasov},
  journal={Journal of Psychopharmacology},
  year={2012},
  volume={26},
  pages={1584 - 1593}
}
Incensole acetate (IA), a constituent of Boswellia resin (‘frankincense’), was previously demonstrated to exhibit an antidepressive-like effect in the Forced Swim Test (FST) in mice following single dose administration (50 mg/kg). Here, we show that acute administration of considerably lower dose (10 mg/kg) IA to selectively bred mice, showing prominent submissive behavior, exerted significant antidepressant-like effects in the FST. Furthermore, chronic administration of 1 or 5 mg/kg per day of… Expand
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