Inbred royals show traces of natural selection

@article{Callaway2013InbredRS,
  title={Inbred royals show traces of natural selection},
  author={Ewen Callaway},
  journal={Nature},
  year={2013}
}
  • E. Callaway
  • Published 19 April 2013
  • Biology, Psychology
  • Nature
Study suggests the Spanish Habsburgs evolved to mute the effects of inbreeding, but other geneticists are unconvinced. 
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Genetic contribution to the aggregation of schizophrenia and bipolar disorder in multiplex consanguineous Pakistani pedigrees

References

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The Role of Inbreeding in the Extinction of a European Royal Dynasty
TLDR
The results indicate that inbreeding at the level of first cousin exerted an adverse effect on survival of 17.8%±12.3, and a statistically significant inbreeding depression for survival to 10 years is detected in the progenies of the Spanish Habsburg kings.
Royal dynasties as human inbreeding laboratories: the Habsburgs
TLDR
Empirical support is provided that human inbreeding depression for some fitness components might be purged by selection within consanguineous populations.
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