Inbred Strain-Specific Effects of Exercise in Wild Type and Biglycan Deficient Mice

@article{Wallace2009InbredSE,
  title={Inbred Strain-Specific Effects of Exercise in Wild Type and Biglycan Deficient Mice},
  author={Joseph M Wallace and Kurtulus Golcuk and Michael D. Morris and David H Kohn},
  journal={Annals of Biomedical Engineering},
  year={2009},
  volume={38},
  pages={1607-1617}
}
Biglycan (bgn)-deficient mice (KO) have defective osteoblasts which lead to changes in the amount and quality of bone. Altered tissue strength in C57BL6/129 (B6;129) KO mice, a property which is independent of tissue quantity, suggests that deficiencies in tissue quality are responsible. However, the response to bgn-deficiency is inbred strain-specific. Mechanical loading influences bone matrix quality in addition to any increase in bone mass or change in bone formation activity. Since many… CONTINUE READING
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