Inborn errors of aldosterone biosynthesis in humans

@article{Shizuta1995InbornEO,
  title={Inborn errors of aldosterone biosynthesis in humans},
  author={Y. Shizuta and T. Kawamoto and Y. Mitsuuchi and Kaoru Miyahara and H. Imura},
  journal={Steroids},
  year={1995},
  volume={60},
  pages={15-21}
}
  • Y. Shizuta, T. Kawamoto, +2 authors H. Imura
  • Published 1995
  • Biology, Medicine
  • Steroids
  • Corticosterone methyl oxidase (CMO) type I and type II deficiencies are inborn errors at the penultimate and ultimate steps in the biosynthesis of aldosterone in humans. Recently, steroid 18-hydroxylase (P450C18), or aldosterone synthase (P450aldo), was shown to be a multifunctional enzyme catalyzing these two steps of aldosterone biosynthesis, i.e., the conversion of corticosterone to 18-hydroxycorticosterone and the subsequent conversion of 18-hydroxycorticosterone to aldosterone. This… CONTINUE READING
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