Inappropriate use of albino animals as models in research

@article{Creel1980InappropriateUO,
  title={Inappropriate use of albino animals as models in research},
  author={Donnell J. Creel},
  journal={Pharmacology Biochemistry and Behavior},
  year={1980},
  volume={12},
  pages={969-977}
}
  • D. Creel
  • Published 1 June 1980
  • Medicine, Biology
  • Pharmacology Biochemistry and Behavior
Sensory-neural, biochemical-metabolic, and physiological anomalies occur in albino mammals. There are ontogenic and biochemical parallels between the senses, peripheral nervous system, endocrine glands, metabolism, and melanin pigmentation. All albino mammals examined have abnormal optic systems. Many drugs cannot be adequately evaluated in an albino model because of melanin's ability to bind and interact with some chemicals. There is evidence that a general reduction in melanin pigment is… 
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Compared to pigmented strains of rats, albino strains are more susceptible to pentobarbital. In such between-strains comparisons, the genetic variable of albinism is confounded with other genetic
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