Inappropriate gold standard bias in cervical cancer screening studies.

  title={Inappropriate gold standard bias in cervical cancer screening studies.},
  author={Robert Gerald Pretorius and Yan-Ping Bao and Jerome Leslie Belinson and Raoul J. Burchette and Jennifer Smith and You-lin Qiao},
  journal={International journal of cancer},
  volume={121 10},
As acetic acid-aided visual inspection (VIA) and colposcopic-directed biopsy miss small >/=cervical intraepithelial neoplasia (CIN) 2, inflation of sensitivity of VIA may occur when colposcopic-directed biopsy is the gold standard for >/=CIN 2. To determine whether such inflation occurs, we reviewed 375 women with >/=CIN 2 from the Shanxi Province Cervical Cancer Screening Study II. These women had positive self or physician-collected tests for high-risk human papillomavirus or abnormal… CONTINUE READING