Inadvertent intrathecal vincristine administration: a neurosurgical emergency. Case report.

@article{Qweider2007InadvertentIV,
  title={Inadvertent intrathecal vincristine administration: a neurosurgical emergency. Case report.},
  author={Maher Qweider and Joachim M. Gilsbach and V. Rohde},
  journal={Journal of neurosurgery. Spine},
  year={2007},
  volume={6 3},
  pages={280-3}
}
Vincristine has a high neurotoxicity level. If given intrathecally by accident, it can cause ascending radiculomyeloencephalopathy, which is almost always fatal. The authors report a rare case in which vincristine was accidentally injected intrathecally into a 32-year-old man. The patient, who had Burkitt lymphoma, was neurologically intact, and it is likely that his survival was made possible due to aggressive neurosurgical therapy. After immediate cerebrospinal fluid (CSF) aspiration… CONTINUE READING
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