Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases.

@article{Fujimoto2004InadequateIO,
  title={Inadequate induction of suppressor of cytokine signaling-1 causes systemic autoimmune diseases.},
  author={Minoru Fujimoto and Hiroko Tsutsui and Ouyang Xinshou and Masanori Tokumoto and Dai Watanabe and Yoshihito Shima and Tomohiro Yoshimoto and Hideki Hirakata and Ichiro Kawase and Kenji Nakanishi and Tadamitsu Kishimoto and Tetsuji Naka},
  journal={International immunology},
  year={2004},
  volume={16 2},
  pages={303-14}
}
Suppressor of cytokine signaling (SOCS)-1 is a cytokine-inducible, negative regulatory molecule of Janus kinases (JAK) and its deficiency causes hyper-response to various cytokines. SOCS-1(-/-) mice spontaneously develop a fatal disease depending on aberrantly activated lymphocytes. Here, we show that partial restoration of SOCS-1 in lymphoid cells rescues SOCS-1(-/-) mice from the early-onset fatal disease, indicating that SOCS-1 expression in vivo is especially required in lymphocytes… CONTINUE READING

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