Corpus ID: 29116313

Inadequate Thyroid Hormone Regulation as the Main Mechanism of Fibromyalgia: A Review of the Evidence

  title={Inadequate Thyroid Hormone Regulation as the Main Mechanism of Fibromyalgia: A Review of the Evidence},
  author={J. Lowe and J. Yellin},
All symptoms and most objectively verified abnormalities among fibromyalgia (FMS) patients are c haracteristic of subsets o f pat ients with hypothyroidism or partial peripheral thyroid hormone r e- sistance. [...] Key Result In several open and blinded treatment trials, thyroid hormone therapy other than T -replace- ment h as re duced or eliminated FMS symptoms a nd many stu dy p atients h ave ceased to meet th e criteria for FMS.Expand
Fibromyalgia, Thyroid Dysfunction and Treatment Modalities
In order to correct thyroid dysfunction and manage symptoms presenting in fibromyalgia patients, a multi-disciplinary approach should be taken incorporating dietary supplements, nutraceuticals, dietary changes and complementary alternative therapies. Expand
Structural Pathology in the Muscles of Subclinical Hypothyroid Patients: Another Call for Early Treatment
hope in us—that the report will motivate more clinicians to provide subclinical hypothyroid patients with early thyroid hormone treatment. Early treatment is likely to relieve the patients’Expand
Theory: Treatments for Prolonged ICU Patients May Provide New Therapeutic Avenues for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
An overview of treatment trials for prolonged intensive care unit (ICU) patients is provided and their relevance for potential treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is theorized. Expand
Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Here the hypothesis is advanced that maladaptive mechanisms that prevent recovery in some intensive care unit (ICU) patients may also underlie Myalgic encephalomyelitis/chronic fatigue syndromeExpand


Effectiveness and Safety of T3 (Triiodothyronine) Therapy for Euthyroid Fibromyalgia
E euthyroid FMS patients with T3 are treated to see if they would respond as do patients with peripheral thyroid hormone resistance syndrome: significant therapeutic effects with supraphysiologic dosages, without target tissue responses typical of thyrotoxicosis. Expand
A metabolic basis for fibromyalgia and its related disorders: the possible role of resistance to thyroid hormone.
Overlapping symptom complexes suggest that chronic fatigue syndrome, Gulf war syndrome, premenstrual syndrome, post traumatic stress disorder, breast implant silicone sensitivity syndrome, bipolar affective disorder, systemic candidiasis, myofascial pain syndrome, and idiopathic environmental intolerance are similar enough to fibromyalgia to merit investigation for possible thyroid resistance. Expand
Evaluation and management of endocrine dysfunction in fibromyalgia.
There is little support for hormone supplementation as a general therapy in the common patient with fibromyalgia, but interventions aimed at pain, fatigue, sleep or mood disturbance, and physical deconditioning may indirectly improve endocrine functioning. Expand
Metabolic Failure as the Cause of Fibromyalgia Syndrome: Exploring the John C. Lowe Thesis
The results of questionnaire analysis, use of the Van Vincent BE-T-A testing, and the author’s clinical experience are consistent with the Lowe thesis that metabolic failure underlies FMS. Expand
A Case-Control Study of Metabolic Therapy for Fibromyalgia
The long-term effectiveness of metabolic therapy for fibromyalgia syndrome (FMS) involving the use of exogenous thyroid honnone was evaluated and matched evaluated but non-treated FMS patients were compared. Expand
Interrelations between fibromyalgia, thyroid autoantibodies, and depression.
The results suggest an association between FM and thyroid autoimmunity is suggested, previously considered as an important confounding factor. Expand
Metabolic Therapy for Hypothyroid and Euthyroid Fibromyalgia
Recovery of these two patients, managed at an independent clinical site, supports the effectiveness of the treatment itself for both hypothyroid and euthyroid FMS. Expand
Thyroid function in patients with fibromyalgia syndrome.
Thyroid function was tested in female patients with primary fibromyalgia syndrome and healthy age matched controls by intravenous injection of thyrotropin-releasing hormone, and both groups exhibited parathyroid hormone levels in the normal range. Expand
Female fibromyalgia patients: lower resting metabolic rates than matched healthy controls.
Patients had lower mRMR and percentages of predicted RMRs, and patients' normal FFW argues against low physical activity as the mechanism, which does not rule out inadequate thyroid hormone regulation. Expand
Lower Resting Metabolic Rate and Basal Body Temperature of Fibromyalgia Patients Compared to Matched Healthy Controls
The resting metabolic rates and body temperatures of fibromyalgia patients previously evaluated at a specialty metabolic clinic were compared with healthy controls to whom they were matched and fibro- myalgia symptom intensity was studied. Expand