Inadequate Thyroid Hormone Regulation as the Main Mechanism of Fibromyalgia: A Review of the Evidence
@inproceedings{Lowe2008InadequateTH, title={Inadequate Thyroid Hormone Regulation as the Main Mechanism of Fibromyalgia: A Review of the Evidence}, author={John C. Lowe and Jackie Yellin}, year={2008} }
All symptoms and most objectively verified abnormalities among fibromyalgia (FMS) patients are c haracteristic of subsets o f pat ients with hypothyroidism or partial peripheral thyroid hormone r e- sistance. [] Key Result In several open and blinded treatment trials, thyroid hormone therapy other than T -replace- ment h as re duced or eliminated FMS symptoms a nd many stu dy p atients h ave ceased to meet th e criteria for FMS.
7 Citations
Structural Pathology in the Muscles of Subclinical Hypothyroid Patients: Another Call for Early Treatment
- Medicine
- 2009
hope in us—that the report will motivate more clinicians to provide subclinical hypothyroid patients with early thyroid hormone treatment. Early treatment is likely to relieve the patients’…
Prevalence and Characterization of Psychological Trauma in Patients with Fibromyalgia: A Cross-Sectional Study
- Psychology, MedicinePain research & management
- 2022
The data highlight the clinical complexity of patients with FM and the role of childhood trauma in the onset and maintenance of FM, as well as the high comorbidity between anxiety, depression, somatic symptoms, and FM.
Theory: Treatments for Prolonged ICU Patients May Provide New Therapeutic Avenues for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
- Medicine, BiologyFrontiers in Medicine
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An overview of treatment trials for prolonged intensive care unit (ICU) patients is provided and their relevance for potential treatment of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is theorized.
Hypothesis: Mechanisms That Prevent Recovery in Prolonged ICU Patients Also Underlie Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
- Biology, MedicineFrontiers in Medicine
- 2021
Here the hypothesis is advanced that maladaptive mechanisms that prevent recovery in some intensive care unit (ICU) patients may also underlie Myalgic encephalomyelitis/chronic fatigue syndrome…
Fibromyalgia, Thyroid Dysfunction and Treatment Modalities
- Medicine, Biology
- 2013
In order to correct thyroid dysfunction and manage symptoms presenting in fibromyalgia patients, a multi-disciplinary approach should be taken incorporating dietary supplements, nutraceuticals, dietary changes and complementary alternative therapies.
References
SHOWING 1-10 OF 246 REFERENCES
Effectiveness and Safety of T3 (Triiodothyronine) Therapy for Euthyroid Fibromyalgia
- Medicine
- 1996
E euthyroid FMS patients with T3 are treated to see if they would respond as do patients with peripheral thyroid hormone resistance syndrome: significant therapeutic effects with supraphysiologic dosages, without target tissue responses typical of thyrotoxicosis.
A metabolic basis for fibromyalgia and its related disorders: the possible role of resistance to thyroid hormone.
- Medicine, BiologyMedical hypotheses
- 2003
Metabolic Failure as the Cause of Fibromyalgia Syndrome: Exploring the John C. Lowe Thesis
- Medicine, Biology
- 2007
The results of questionnaire analysis, use of the Van Vincent BE-T-A testing, and the author’s clinical experience are consistent with the Lowe thesis that metabolic failure underlies FMS.
A Case-Control Study of Metabolic Therapy for Fibromyalgia
- Medicine
- 1998
The long-term effectiveness of metabolic therapy for fibromyalgia syndrome (FMS) involving the use of exogenous thyroid honnone was evaluated and matched evaluated but non-treated FMS patients were compared.
Interrelations between fibromyalgia, thyroid autoantibodies, and depression.
- Medicine, BiologyThe Journal of rheumatology
- 2004
The results suggest an association between FM and thyroid autoimmunity is suggested, previously considered as an important confounding factor.
Metabolic Therapy for Hypothyroid and Euthyroid Fibromyalgia
- Medicine
- 1997
Recovery of these two patients, managed at an independent clinical site, supports the effectiveness of the treatment itself for both hypothyroid and euthyroid FMS.
Female fibromyalgia patients: lower resting metabolic rates than matched healthy controls.
- MedicineMedical science monitor : international medical journal of experimental and clinical research
- 2006
Patients had lower mRMR and percentages of predicted RMRs, and patients' normal FFW argues against low physical activity as the mechanism, which does not rule out inadequate thyroid hormone regulation.
Lower Resting Metabolic Rate and Basal Body Temperature of Fibromyalgia Patients Compared to Matched Healthy Controls
- Medicine
- 2006
The resting metabolic rates and body temperatures of fibromyalgia patients previously evaluated at a specialty metabolic clinic were compared with healthy controls to whom they were matched and fibro- myalgia symptom intensity was studied.
Thyroid dysfunction in rheumatoid arthritis: a controlled prospective survey.
- MedicineAnnals of the rheumatic diseases
- 1993
Thyroid dysfunction is seen at least three times more often in women with RA than in Women with similar demographic features with non-inflammatory rheumatic diseases such as osteoarthritis and fibromyalgia.
Impaired growth hormone secretion in fibromyalgia patients: evidence for augmented hypothalamic somatostatin tone.
- Medicine, BiologyArthritis and rheumatism
- 2002
It is surmised that the defective GH response to exercise in FM patients probably results from increased levels of somatostatin, a hypothalamic hormone that inhibits GH secretion.