Inadequacies of minimum spanning trees in molecular epidemiology.

  title={Inadequacies of minimum spanning trees in molecular epidemiology.},
  author={Stephen J. Salipante and Barry G. Hall},
  journal={Journal of clinical microbiology},
  volume={49 10},
Minimum spanning trees (MSTs) are frequently used in molecular epidemiology research to estimate relationships among individual strains or isolates. Nevertheless, there are significant caveats to MST algorithms that have been largely ignored in molecular epidemiology studies and that have the potential to confound or alter the interpretation of the results of those analyses. Specifically, (i) presenting a single, arbitrarily selected MST illustrates only one of potentially many equally optimal… CONTINUE READING
Highly Cited
This paper has 43 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.
20 Citations
25 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 20 extracted citations


Publications referenced by this paper.
Showing 1-10 of 25 references

Molecular epidemiology of pneumococci obtained from Gambian children aged 2-29 months with invasive pneumococcal disease during a trial of a 9-valent pneumococcal conjugate vaccine

  • M Antonio
  • BMC Infect
  • 2008

Similar Papers

Loading similar papers…