Inadequacies of minimum spanning trees in molecular epidemiology.

@article{Salipante2011InadequaciesOM,
  title={Inadequacies of minimum spanning trees in molecular epidemiology.},
  author={Stephen J. Salipante and Barry G. Hall},
  journal={Journal of clinical microbiology},
  year={2011},
  volume={49 10},
  pages={3568-75}
}
Minimum spanning trees (MSTs) are frequently used in molecular epidemiology research to estimate relationships among individual strains or isolates. Nevertheless, there are significant caveats to MST algorithms that have been largely ignored in molecular epidemiology studies and that have the potential to confound or alter the interpretation of the results of those analyses. Specifically, (i) presenting a single, arbitrarily selected MST illustrates only one of potentially many equally optimal… CONTINUE READING
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