Inactivity amplifies the catabolic response of skeletal muscle to cortisol.

@article{Ferrando1999InactivityAT,
  title={Inactivity amplifies the catabolic response of skeletal muscle to cortisol.},
  author={Arny A. Ferrando and Charles A. Stuart and Melinda Sheffield-Moore and Robert R. Wolfe},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1999},
  volume={84 10},
  pages={3515-21}
}
Severe injury or trauma is accompanied by both hypercortisolemia and prolonged inactivity or bed rest (BR). Trauma and BR alone each result in a loss of muscle nitrogen, albeit through different metabolic alterations. Although BR alone can result in a 2-3% loss of lean body mass, the effects of severe trauma can be 2- to 3-fold greater. We investigated the combined effects of hypercortisolemia and prolonged inactivity on muscle protein metabolism in healthy volunteers. Six males were studied… CONTINUE READING