Inactive yet indispensable: the tale of Jarid2

  title={Inactive yet indispensable: the tale of Jarid2},
  author={David Landeira and Amanda G Fisher},
  booktitle={Trends in cell biology},
Methylation of histone tails is believed to be important for the establishment and inheritance of gene expression programs during development. Jarid2/Jumonji is the founding member of a family of chromatin modifiers with histone demethylase activity. Although Jarid2 contains amino acid substitutions that are thought to abolish its catalytic activity, it is essential for the development of multiple organs in mice. Recent studies have shown that Jarid2 is a component of the polycomb repressive… CONTINUE READING


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