Inactive C-terminal telomerase reverse transcriptase insertion splicing variants are dominant-negative inhibitors of telomerase.

@article{Zhu2014InactiveCT,
  title={Inactive C-terminal telomerase reverse transcriptase insertion splicing variants are dominant-negative inhibitors of telomerase.},
  author={Shusen Zhu and Philippe Rousseau and Catherine Lauzon and Valentina Gandin and Ivan Topisirovic and Chantal Autexier},
  journal={Biochimie},
  year={2014},
  volume={101},
  pages={93-103}
}
Maintenance of telomere length and structure is essential for cell survival. Telomere synthesis is mediated by the ribonucleoprotein telomerase in 90% of cancer cells, and is regulated mainly by transcription of the human telomerase reverse transcriptase subunit, hTERT. However, transcriptome analysis reveals complex splicing patterns and to date, twenty-two alternatively-spliced hTERT mRNAs have been reported, yet their functions have not been fully elucidated. The best characterized hTERT… CONTINUE READING
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