Inactivation of voltage-activated Na(+) currents contributes to different adaptation properties of paired mechanosensory neurons.

@article{Torkkeli2001InactivationOV,
  title={Inactivation of voltage-activated Na(+) currents contributes to different adaptation properties of paired mechanosensory neurons.},
  author={P{\"a}ivi H. Torkkeli and Shin-ichi Sekizawa and Andrew S. French},
  journal={Journal of neurophysiology},
  year={2001},
  volume={85 4},
  pages={
          1595-602
        }
}
Voltage-activated sodium current (I(Na)) is primarily responsible for the leading edge of the action potential in many neurons. While I(Na) generally activates rapidly when a neuron is depolarized, its inactivation properties differ significantly between different neurons and even within one neuron, where I(Na) often has slowly and rapidly inactivating components. I(Na) inactivation has been suggested to regulate action potential firing frequency in some cells, but no clear picture of this… 
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References

SHOWING 1-10 OF 28 REFERENCES
Low-voltage-activated calcium current does not regulate the firing behavior in paired mechanosensory neurons with different adaptation properties.
TLDR
It is concluded that LVA-Ca(2+) channels in the somata, and possible in the dendrites, of these neurons open in response to the depolarization caused by receptor current and by the voltage-activated Na(+) current that produces action potential(s).
Voltage-activated potassium outward currents in two types of spider mechanoreceptor neurons.
TLDR
It is concluded that, although differences in the activation kinetics of the voltage-activated K+ currents could contribute to the difference in the adaptation behavior of type A and type B neurons, they are not major factors.
Evidence for two transient sodium currents in the frog node of Ranvier.
TLDR
It is concluded that the inactivatable Na current of the nodal membrane is made up of two components corresponding to two different and interconvertible forms of the Na channel.
Different spatial distributions of sodium channels in the slowly and rapidly adapting stretch receptor neuron of the crayfish
Slowly inactivating outward currents in a cuticular mechanoreceptor neuron of the cockroach (Periplaneta americana).
TLDR
The basic electrophysiological properties of the cockroach femoral tactile spine neuron were studied using discontinuous (switching) single-electrode current- and voltage-clamp recordings and revealed that the TEA-sensitive K+ current was the major component of action potential repolarization but that it did not effect the frequency ofaction potentials evoked by steady depolarization.
Large conductance Ca(2+)‐activated K+ channels are involved in both spike shaping and firing regulation in Helix neurones.
TLDR
The role of BK‐type calcium‐dependent K+ channels (K+Ca) in cell firing regulation was evaluated by performing whole‐cell voltage clamp and patch clamp experiments on the U cell neurones in the snail Helix pomatia, finding that K+Ca channels appeared to play no role in shaping the interspike trajectory.
The A-current: how ubiquitous a feature of excitable cells is it?
Patch-clamp Study of the Properties of the Sodium Current in Cockroach Single Isolated Adult Aminergic Neurones
TLDR
The results suggest that the Na + channels of DUM neurones have more than one open state and/or more-than-one inactivated state.
Impulse firing in the slowly adapting stretch receptor neurone of lobster and its numerical simulation.
TLDR
In the living cell firing adaptation, it can be concluded that the initial phase is mainly caused by the slow Na inactivation, while the later phase is due to a slow Na+ influx dependent pump current activation.
Low-threshold, persistent sodium current in rat large dorsal root ganglion neurons in culture.
TLDR
The low-threshold current is a TTX-sensitive, persistent Na+ current that contributed to steady-state membrane current from at least -70 mV to 0 mV, a wider potential range than predicted by activation-inactivation gating overlap for transient Na+Current.
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