Inactivation of thrombin in heparin-PVA coated tubes.

  title={Inactivation of thrombin in heparin-PVA coated tubes.},
  author={G Rollason and Michael Vivian Sefton},
  journal={Journal of biomaterials science. Polymer edition},
  volume={1 1},
Heparin, immobilized to polyvinyl alcohol by reaction with glutaraldehyde (heparin-PVA), retained its ability to accelerate the antithrombin III inactivation of thrombin, in a recirculating flow loop using heparin-PVA coated polyethylene tubes. The extent of inactivation, for a constant flow time, was approximately constant over ten cycles of exposure to thrombin and antithrombin III, suggesting that the immobilized heparin was reusable, as expected from the catalytic nature of non-immobilized… CONTINUE READING

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