Inactivation of thermogenic UCP1 as a historical contingency in multiple placental mammal clades

@inproceedings{Gaudry2017InactivationOT,
  title={Inactivation of thermogenic UCP1 as a historical contingency in multiple placental mammal clades},
  author={Michael J. Gaudry and Martin Jastroch and Jason R Treberg and Michael Hofreiter and Johanna L. A. Paijmans and James Starrett and Nathan Wales and Anthony V. Signore and Mark S. Springer and Kevin L Campbell},
  booktitle={Science Advances},
  year={2017}
}
Mitochondrial uncoupling protein 1 (UCP1) is essential for nonshivering thermogenesis in brown adipose tissue and is widely accepted to have played a key thermoregulatory role in small-bodied and neonatal placental mammals that enabled the exploitation of cold environments. We map ucp1 sequences from 133 mammals onto a species tree constructed from a ~51-kb sequence alignment and show that inactivating mutations have occurred in at least 8 of the 18 traditional placental orders, thereby… CONTINUE READING
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