Inactivation of the vitamin D receptor enhances susceptibility of murine skin to UV-induced tumorigenesis.

@article{Ellison2008InactivationOT,
  title={Inactivation of the vitamin D receptor enhances susceptibility of murine skin to UV-induced tumorigenesis.},
  author={Tara I Ellison and Molly McVoy Kerry Smith and Anita C. Gilliam and Paul N. MacDonald},
  journal={The Journal of investigative dermatology},
  year={2008},
  volume={128 10},
  pages={2508-17}
}
1,25-Dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) is the biologically active ligand for the vitamin D receptor (VDR). VDR(-/-) mice have a hair follicle-cycling defect resulting in alopecia. However, mice lacking 25-hydroxyvitamin D(3) 1alpha-hydroxylase (CYP27B1(-/-)), and having no circulating 1,25(OH)(2)D(3), have normal follicular function. These mouse models indicate that VDR functions independently of 1,25(OH)(2)D(3) in regulating hair-follicle cycling. Here, we show that VDR(-/-) mice rapidly… CONTINUE READING