Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation.

@article{Furgeson2010InactivationOT,
  title={Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation.},
  author={Seth B. Furgeson and Peter A Simpson and Insun Park and Vicki Vanputten and Henrick N Horita and Christopher D. Kontos and Raphael A Nemenoff and Mary Weiser-Evans},
  journal={Cardiovascular research},
  year={2010},
  volume={86 2},
  pages={274-82}
}
AIMS Phosphatase and tensin homolog (PTEN) is implicated as a negative regulator of vascular smooth muscle cell (SMC) proliferation and injury-induced vascular remodelling. We tested if selective depletion of PTEN only in SMC is sufficient to promote SMC phenotypic modulation, cytokine production, and enhanced neointima formation. METHODS AND RESULTS Smooth muscle marker expression and induction of pro-inflammatory cytokines were compared in cultured SMC expressing control or PTEN-specific… CONTINUE READING