Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes

@article{Gennip2009InactivationOT,
  title={Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes},
  author={M. van Gennip and L. Christensen and Morten Alhede and R. Phipps and P. Jensen and L. Christophersen and S. J. Pamp and C. Moser and P. J. Mikkelsen and A. Koh and T. Tolker-Nielsen and G. Pier and N. H{\O}iby and M. Givskov and T. Bjarnsholt},
  journal={APMIS},
  year={2009},
  volume={117}
}
Many of the virulence factors produced by the opportunistic human pathogen Pseudomonas aeruginosa are quorum‐sensing (QS) regulated. Among these are rhamnolipids, which have been shown to cause lysis of several cellular components of the human immune system, e.g. monocyte‐derived macrophages and polymorphonuclear leukocytes (PMNs). We have previously shown that rhamnolipids produced by P. aeruginosa cause necrotic death of PMNs in vitro. This raises the possibility that rhamnolipids may… Expand
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