Inactivation of the pyruvate dehydrogenase complex of Escherichia coli by fluoropyruvate.

Abstract

The pyruvate dehydrogenase complex (PDH complex) of Escherichia coli and its pyruvate dehydrogenase component (E1) are rapidly inactivated by low concentrations of fluoropyruvate in a thiamin pyrophosphate (TPP) dependent process. The inactivation rates for the PDH complex and for its E1 component are similar. Pyruvate protects the PDH complex and the E1… (More)

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Cite this paper

@article{Flournoy1989InactivationOT, title={Inactivation of the pyruvate dehydrogenase complex of Escherichia coli by fluoropyruvate.}, author={Douglas S. Flournoy and Pascal Frey}, journal={Biochemistry}, year={1989}, volume={28 25}, pages={9594-602} }