Inactivation of the prelimbic, but not infralimbic, prefrontal cortex impairs the contextual control of response conflict in rats.

@article{Marquis2007InactivationOT,
  title={Inactivation of the prelimbic, but not infralimbic, prefrontal cortex impairs the contextual control of response conflict in rats.},
  author={Jean-Philippe Marquis and Simon Killcross and Josephine E. Haddon},
  journal={The European journal of neuroscience},
  year={2007},
  volume={25 2},
  pages={559-66}
}
One fundamental function of the prefrontal cortex (PFC) is to guide context-appropriate behaviour in situations of response conflict. Haddon and Killcross recently developed a task in rats which mimics some aspects of response conflict seen in human cognitive paradigms such as the Stroop task. Using this paradigm they demonstrated that large PFC lesions including the prelimbic (PL), infralimbic (IL) and anterior cingulate cortices (ACC) selectively impaired performance on incongruent trials… CONTINUE READING

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