Inactivation of the inhibitory kappaB protein kinase/nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis.

@article{DiazMeco1999InactivationOT,
  title={Inactivation of the inhibitory kappaB protein kinase/nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis.},
  author={Maria-Teresa Diaz-Meco and Marı́a Jos{\'e} Lallena and Alicia Monjas and Sonia Frutos and J Moscat},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 28},
  pages={
          19606-12
        }
}
Par-4 is a novel protein identified in cells undergoing apoptosis. The ability of Par-4 to promote apoptotic cell death is dependent on the binding and inactivation of the atypical protein kinases C (PKCs). This subfamily of kinases has been reported to control nuclear factor kappaB (NF-kappaB) through the regulation of the IkappaB kinase activity. NF-kappaB activation by tumor necrosis factor alpha (TNFalpha) provides a survival signal that impairs the TNFalpha-induced apoptotic response. We… CONTINUE READING
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