Inactivation of the human immunodeficiency virus type 1 inhibitory elements allows Rev-independent expression of Gag and Gag/protease and particle formation.

@article{Schneider1997InactivationOT,
  title={Inactivation of the human immunodeficiency virus type 1 inhibitory elements allows Rev-independent expression of Gag and Gag/protease and particle formation.},
  author={Ralf Schneider and Mark J. Campbell and George Nasioulas and Barbara K Felber and George N Pavlakis},
  journal={Journal of virology},
  year={1997},
  volume={71 7},
  pages={4892-903}
}
The expression of gag, pol, and env of human immunodeficiency virus type 1 (HIV-1) depends on the presence of the viral Rev protein. This dependence is, at least in part, due to the presence of negatively acting sequences (inhibitory or instability elements [INS]) located within unspliced and partially spliced mRNAs. The positive interaction of Rev with the Rev-responsive element in these mRNAs counteracts the negative effects of the inhibitory sequences. Here, we demonstrate that in addition… CONTINUE READING
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