Inactivation of the gene for the nuclear receptor tailless in the brain preserving its function in the eye.

@article{Belz2007InactivationOT,
  title={Inactivation of the gene for the nuclear receptor tailless in the brain preserving its function in the eye.},
  author={Thorsten Belz and Hai-Kun Liu and Dagmar Bock and Andrea Takacs and Miriam Vogt and Tim M. Wintermantel and Christiane Brandwein and Peter Gass and Erich Greiner and Guenther Schuetz},
  journal={The European journal of neuroscience},
  year={2007},
  volume={26 8},
  pages={2222-7}
}
During embryogenesis, tailless, an orphan member of the nuclear receptor family, is expressed in the germinal zones of the brain and the developing retina, and is involved in regulating the cell cycle of progenitor cells. Consequently, a deletion of the tailless gene leads to decreased cell number with associated anatomical defects in the limbic system, the cortex and the eye. These structural abnormalities are associated with blindness, increased aggressiveness, poor performance in learning… CONTINUE READING