Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi.

@article{Seshu2006InactivationOT,
  title={Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi.},
  author={Janakiram Seshu and Mar{\'i}a Dolores Esteve-Gassent and Maria Labandeira-Rey and Jung Hwa Kim and Jerome P. Trzeciakowski and Magnus H{\"o}{\"o}k and Jonathan T. Skare},
  journal={Molecular microbiology},
  year={2006},
  volume={59 5},
  pages={1591-601}
}
Borrelia burgdorferi, the aetiological agent of Lyme disease, utilizes multiple adhesins to interact with both the arthropod vector and mammalian hosts it colonizes. One such adhesive molecule is a surface-exposed fibronectin-binding lipoprotein, designated BBK32. Previous characterization of BBK32-mediated fibronectin binding has been limited to biochemical analyses due to the difficulty in mutagenizing infectious isolates of B. burgdorferi. Here we report an alternative method to inactivate… CONTINUE READING
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