Inactivation of the cytochrome P450 gene CYP82E2 by degenerative mutations was a key event in the evolution of the alkaloid profile of modern tobacco.

@article{Chakrabarti2007InactivationOT,
  title={Inactivation of the cytochrome P450 gene CYP82E2 by degenerative mutations was a key event in the evolution of the alkaloid profile of modern tobacco.},
  author={Manohar Chakrabarti and Karen M. Meekins and Lily B Gavilano and Balazs Siminszky},
  journal={The New phytologist},
  year={2007},
  volume={175 3},
  pages={565-74}
}
The alkaloid profile of cultivated tobacco (Nicotiana tabacum) is different from that of its two progenitors, Nicotiana sylvestris and Nicotiana tomentosiformis, in that tobacco accumulates nicotine as the most abundant alkaloid, while its ancestors convert nicotine to nornicotine in the senescing leaf. The nicotine-retaining phenotype of tobacco is thought… CONTINUE READING