Inactivation of the Peptide-Sensitive Channel from the Yeast Mitochondrial Outer Membrane: Properties, Sensitivity to Trypsin and Modulation by a Basic Peptide

@article{Pelleschi1997InactivationOT,
  title={Inactivation of the Peptide-Sensitive Channel from the Yeast Mitochondrial Outer Membrane: Properties, Sensitivity to Trypsin and Modulation by a Basic Peptide},
  author={M. Pelleschi and J. P. Henry and Michel Thieffry},
  journal={The Journal of Membrane Biology},
  year={1997},
  volume={156},
  pages={37-44}
}
The yeast Peptide Sensitive Channel (PSC), a cationic channel of the mitochondrial outer membrane closes with slow kinetics at potentials of either polarity. The properties of this inactivation closely resemble those of the Voltage-Dependent Anion Channel (VDAC) slow kinetics closures. Addition of trypsin to one compartment suppresses the inactivation observed when this compartment is made positive, but does not affect the inactivation observed at potentials of reverse polarity. Both sides of… CONTINUE READING