Inactivation of the PTEN gene by mutation, exonic deletion, and loss of transcript in human oral squamous cell carcinomas.

@article{Shin2002InactivationOT,
  title={Inactivation of the PTEN gene by mutation, exonic deletion, and loss of transcript in human oral squamous cell carcinomas.},
  author={K S Shin and Jin-man Kim and Kyong Su Rho and Kyung-hee Park and J Oh and Byung-Moo Min},
  journal={International journal of oncology},
  year={2002},
  volume={21 5},
  pages={997-1001}
}
PTEN, a tumor suppressor gene, has been found to be inactivated by structural abnormalities or epigenetic changes in several types of human cancers. Recently, several studies have also suggested the possibility that the PTEN gene is a target of genomic instability in human cancers displaying microsatellite instability (MSI). To investigate the role of PTEN in human oral squamous cell carcinomas, we screened the entire coding region sequences and examined the expression of the PTEN gene in 81… CONTINUE READING

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