Inactivation of the Interoceptive Insula Disrupts Drug Craving and Malaise Induced by Lithium

@article{Contreras2007InactivationOT,
  title={Inactivation of the Interoceptive Insula Disrupts Drug Craving and Malaise Induced by Lithium},
  author={Marco Contreras and Francisco C{\'e}ric and Fernando Torrealba},
  journal={Science},
  year={2007},
  volume={318},
  pages={655 - 658}
}
Addiction profoundly alters motivational circuits so that drugs become powerful reinforcers of behavior. The interoceptive system continuously updates homeostatic and emotional information that are important elements in motivational decisions. We tested the idea that interoceptive information is essential in drug craving and in the behavioral signs of malaise. We inactivated the primary interoceptive cortex in amphetamine-experienced rats, which prevented the urge to seek amphetamine in a place… 

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